Citations 1
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles
Hong, Siting , Huang, Weijun , Zhu, Xiangyang , Tang, Hui , Krier, James D., Li, Xing , Lu, Bo, Gandhi, Deep , Jordan, Kyra L., Saadiq, Ishran M. , Lerman, Lilach O. , Eirin, Alfonso , Lerman, Lilach O , Xing, Li , Lu, Bo, Lerman, Amir , Eirin, Alfonso
American Journal of Physiology-Heart and Circulatory Physiology | June 9, 2023 | Volume: 325 | Issue: 1 | Pages: H163-H171
Injection of A-MSC-derived EVs harvested from patients who are lean can resolve myocardial injury in mice with experimental renovascular hypertension more effectively than A-MSC-derived EVs from patients with obesity. These observations underscore and might have important ramifications for the self-healing capacity of patients with obesity and for the use of autologous EVs as a regenerative tool.