Citations 1
Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study
Ziadé, Nelly , Aoude, Marc, Hmamouchi, Ihsane , Naveen, R, Sen, Parikshit , Joshi, Mrudula , Agarwal, Vishwesh , Kardeş, Sinan , Day, Jessica , Milchert, Marcin , Gheita, Tamer A. , Salim, Babur , Velikova, Tsvetelina , Parodis, Ioannis , Nikiphorou, Elena , Tan, Ai Lyn , Kuwana, Masataka , Chinoy, Hector , Agarwal, Vikas , Gupta, Latika, Group, the COVAD Study, Singh, Yogesh Preet , Pandya, Sapan C , Sharma, Aman , Manoj, Manesh , Patro, Pradeepta Sekhar , Ajmani, Sajal, Chowdhury, Abhra Chandra , Shenoy, Padnamabha, Asranna, Ajay, Bommakanti, Keerthi Talari, Shukla, Anuj , Pandey, Arun Kumar R, Pauling, John D , Sambataro, Gianluca , Atzeni, Fabiola , Parisi, Simone , Bocci, Elena Bartoloni, Sainaghi, Pier Paolo , Orsolini, Giovanni , Angelis, Rossella De , Danielli, Maria Giovanna, Tehozol, Erick Adrian Zamora , Loarce‐Martos, Jesus , Prieto‐González, Sergio , González, Raquel , Nakashima, Ran , Sato, Shinji , Kimura, Naoki , Kaneko, Yuko , Tomaras, Stylianos , Aharonov, Or, Maurier, F. , Meyer, Alain, Nagy‐Vincze, Melinda , Limaye, Vidya , Hudson, Marie , Landon‐Cardinal, Océane , Shaharir, Syahrul Sazliyana , Zuleta, Wilmer Gerardo Rojas, Silva, José António Pereira, Ravichandran, Naveen , Gupta, Latika , Agarwal, Vikas , Naveen, R , Lilleker, James B , Sen, Parikshit , Joshi, Mrudula , Agarwal, Vishwesh , Kardes, Sinan , Day, Jessica , Makol, Ashima , Milchert, Marcin , Gheita, Tamer , Salim, Babur , Velikova, Tsvetelina , Gracia-Ramos, Abraham Edgar , Parodis, Ioannis , Nikiphorou, Elena , Chatterjee, Tulika , Tan, Ai Lyn , Saavedra, Miguel A , Shinjo, Samuel Katsuyuki , Knitza, Johannes , Kuwana, Masataka , Nune, Arvind , Cavagna, Lorenzo , Distler, Oliver , Chinoy, Hector , Agarwal, Vikas , Aggarwal, Rohit , Gupta, Latika , Ziade, Nelly , Pauling, John D , Zamora Tehozol, Erick Adrian , De Angelis, Rossella , Singh, Yogesh Preet , Makol, Ashima , Gracia‐Ramos, Abraham Edgar , Chatterjee, Tulika , Shinjo, Samuel Katsuyuki , Nune, Arvind , Distler, Oliver , Aggarwal, Rohit , Group, the COVAD Study, Barman, Bhupen , Ranjan, Rajiv , Jain, Avinash , Pilania, Rakesh Kumar , Gupta, Vikas , Kavadichanda, Chengappa G. , Ajmani, Sajal , Phatak, Sanat B. , Goswami, Rudra P , Mathew, Ashish Jacob , Chandwar, Kunal , Cansu, Döndü Üsküdar , Wincup, Chris , Papa, Nicoletta Del , Govoni, Marcello , Bocci, Elena Bartoloni, Sebastiani, Gian Domenico , Fusaro, Enrico , Sebastiani, Marco , Quartuccio, Luca , Franceschini, Franco , Venerito, Vincenzo , Traboco, Lisa S , Wibowo, Suryo Anggoro Kusumo , Rojas Serrano, Jorge , Torre, Ignacio García‐De La , Gonzalez, Raquel Aranega, Yoshida, Akira , Gromova, Margarita Aleksandrovna , Hoff, Leonardo Santos , Giannini, Margherita , Campagne, Julien , Meyer, Alain , Langguth, Daman , Needham, Merrilee , Srivastav, Nilesh , Silva, José António Pereira, Fonseca, João Eurico , Zimba, Olena
Rheumatology | May 25, 2023 | Volume: 63 | Issue: 3 | Pages: 657-664
Abstract Objectives We aimed to explore current practice and interregional differences in the treatment of idiopathic inflammatory myopathies (IIMs). We triangulated these observations considering countries' gross national income (GNI), disease subtypes, and symptoms using patient-reported information. Methods A cross-sectional ancillary analysis of the ‘COVID-19 vaccination in auto-immune disease’ (COVAD) e-survey containing demographic characteristics, IIM subtypes (DM, PM, IBM, anti-synthetase syndrome [ASSD], immune-mediated necrotizing myopathy [IMNM], overlap myopathies [OM]), current symptoms (surrogate for organ involvement) and treatments (corticosteroids [CS], immunomodulators [IM], i.e. antimalarials, immunosuppressants [IS], IVIG, biologic treatments and targeted-synthetic small molecules). Treatments were presented descriptively according to continents, GNI, IIM and organ involvement, and associated factors were analysed using multivariable binary logistic regressions. Results Of 18 851 respondents from 94 countries, 1418 with IIM were analysed (age 61 years, 62.5% females). DM (32.4%), IBM (24.5%) and OM (15.8%) were the most common subtypes. Treatment categories included IS (49.4%), CS (38.5%), IM (13.8%) and IVIG (9.4%). Notably, treatments varied across regions, GNI categories (IS mostly used in higher-middle income, IM in lower-middle income, IVIG and biologics largely limited to high-income countries), IIM subtypes (IS and CS associated with ASSD, IM with OM and DM, IVIG with IMNM, and biologic treatments with OM and ASSD) and disease manifestations (IS and CS with dyspnoea). Most inter-regional treatment disparities persisted after multivariable analysis. Conclusion We identified marked regional treatment disparities in a global cohort of IIM. These observations highlight the need for international consensus-driven management guidelines considering patient-centred care and available resources.