Citations 1
Failure of mobilization of hematopoietic stem cells associated with elevated serum levels of anti‐CD38 monoclonal antibody
Murray, David , Buadi, Francis K. , Gertz, Morie A. , Yadav, Udit , Kumar, Shaji , Gonsalves, Wilson I. , Seth, Abhishek, Buadi, Francis K , Gertz, Morie A , Kumar, Shaji K , Gonsalves, Wilson , Seth, Abhishek
European Journal of Haematology | May 20, 2023 | Volume: 111 | Issue: 2 | Pages: 318-321
AbstractDaratumumab is an anti‐CD38 antibody that is increasingly incorporated in induction regimens for treating patients with newly diagnosed multiple myeloma (NDMM). Previous reports have demonstrated a lower yield of hematopoietic stem cells (HSCs) after induction with daratumumab; however, none of them reported a failure to collect an adequate number of HSCs. We describe a case of adequate HSC mobilization failure in a patient who inadvertently received excessive doses of daratumumab and was confirmed by higher‐than‐expected circulating levels of daratumumab by mass spectrometry. Eventual clearance of circulating daratumumab was associated with the successful mobilization and harvesting of HSCs.