Citations 3
Synthesis and preliminary evaluation of cardiac imaging with [ 68 Ga]Ga-NOTA-CTP in normal and infarcted CD1 mice
Gundam, Surendra Reddy, Kethamreddy, Manasa, Rivera, Alexander, Bansal, Aditya , Krol, Viktoria, Sahagun, Daniella, Johnson, Derek R. , Lowe, Val J. , Gundam, Surendra R. , Rivera, Andy González, Sahagun, Daniella A , Kusmirek, Joanna E. , Johnson, Derek R , Zahid, Maliha , Pandey, Mukesh K , Pandey, Mukesh K. , Gundam, Surendra R.
RSC Pharmaceutics | May 29, 2025 | Volume: 2 | Issue: 4 | Pages: 691-702
The radiotracer [ 68 Ga]Ga-NOTA-CTP was evaluated in healthy and diseased CD1 mice with myocardial infarction following ligation of the left anterior descending artery.
Synthesis and Application of 1-[18F]Fluoro-4-isothiocyanatobenzene for Radiofluorination of Peptides in Aqueous Medium
Gundam, Surendra Reddy, Callstrom, Matthew R. , Pandey, Mukesh K. , Gundam, Surendra R. , Callstrom, Mathew R, Pandey, Mukesh K , Gundam, Surendra Reddy, Gundam, Surendra R.
The Journal of Organic Chemistry | December 13, 2024 | Volume: 90 | Issue: 1 | Pages: 458-470
Comparison of [18F]F‐CNBI and [18F]F‐CNPIFE as Positron Emission Tomography Probes for Noninvasive Imaging of Glycogen Synthase Kinase‐3 in Normal Mice
Stein, Heather M., Gundam, Surendra R. , Bansal, Aditya , Curran, Geoffry L., DeGrado, Timothy R. , Frye, Mark A. , Port, John D. , Lowe, Val J. , Murray, Melissa E. , Pandey, Mukesh K. , Port, John D , Murray, Melissa E , Pandey, Mukesh K , Stein, Heather M., Gundam, Surendra R. , Nelson, Nicholas R.
European Journal of Organic Chemistry | October 27, 2022 | Volume: 26 | Issue: 3 | Pages: No page available
AbstractGlycogen synthase kinase‐3 α/β is involved in dysregulation of neuronal tau protein in Alzheimer's disease (AD). There is an unmet clinical need for a blood‐brain barrier (BBB) permeable positron emission tomography (PET) probe for imaging of GSK‐3α/β in the brain to understand the pathogenesis of AD. Herein, we synthesized two PET probes, [18F]F‐CNBI and [18F]F‐CNPIFE, and evaluated their BBB permeability and affinity towards GSK‐3α/β. [19F]F‐CNPIFE showed higher in‐vitro binding towards GSK‐3α/β (IC50=19.4±2.5 nM; n=3, for GSK‐3α, IC50=19.4±3.8 nM; n=3, for GSK‐3β) compared to [19F]F‐CNBI (IC50=107.6±26.0 nM; n=4, for GSK‐3α, IC50=105.3±18.2 nM; n=3, for GSK‐3β). [18F]F‐CNPIFE showed 9.5‐fold higher brain uptake than [18F]F‐CNBI, in normal FVB/NJ mice, which was increased by additional 1.5‐fold on co‐administration of [19F]F‐CNPIFE with respect to [18F]F‐CNBI. Overall, [18F]F‐CNPIFE is a promising PET probe for GSK‐3α/β imaging and warrants further evaluation in an AD mouse model.