Citations 1
Molecular Epidemiology of Escherichia coli Sequence Type 131 and Its H30 and H30-Rx Subclones among Extended-Spectrum-β-Lactamase-Positive and -Negative E. coli Clinical Isolates from the Chicago Region, 2007 to 2010
Banerjee, Ritu , Robicsek, Ari , Kuskowski, Michael A., Porter, Stephen B. , Johnston, Brian , Sokurenko, Evgeni V. , Tchesnokova, Veronika , Price, Lance B. , Johnson, James R.
Antimicrobial Agents and Chemotherapy | October 1, 2013 | Volume: 57 | Issue: 12 | Pages: 6385-6388
ABSTRACT We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes ( iha , sat , and iutA ) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.