Citations 1
Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C
Berbert, Laura , Young, Cameron C. , Feldstein, Leora R. , Zambrano, Laura D. , Kücükak, Suden, Newhams, Margaret M. , Miller, Kristen , FitzGerald, Madyson M., He, Jie , Halasa, Natasha , Loftis, Laura L. , Walker, Tracie C. , Gertz, Shira J. , Tarquinio, Keiko M. , Fitzgerald, Julie C. , Kong, Michele , Schuster, Jennifer E. , Mack, Elizabeth H. , Rowan, Courtney M. , Staat, Mary Allen , Zinter, Matt S. , Irby, Katherine , Crandall, Hillary , Flori, Heidi R. , Cullimore, Melissa L. , Nofziger, Ryan A. , Gaspers, Mary Glas , Hume, Janet R. , Levy, Emily R. , Chen, Sabrina , Patel, Manish M. , Weller, Edie, Campbell, Angela P. , Randolph, Adrienne G. , Investigators, for the Overcoming COVID-19, Martin, Lora , Malloch, Lacy , Levy, Emily R , Young, Cameron C , Randolph, Adrienne G , Kong, Michele , Hume, Janet R , Staat, Mary A , Gertz, Shira J , Maddux, Aline B. , Miller, Kristen R. , Cvijanovich, Natalie Z , Schwartz, Stephanie P. , Hobbs, Charlotte V. , Shein, Steven L. , Tenforde, Mark W. , Investigators, for the Overcoming COVID-19
Pediatrics | June 29, 2022 | Volume: 150 | Issue: 3 | Pages: No page available
OBJECTIVES To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C). METHODS Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). RESULTS Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04–1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06–1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55–6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35–4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C). CONCLUSIONS Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.