Wang, Zhenyu
Mayo Clinic
University of Arkansas for Medical Sciences
Citations 1
3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Yan, Yuqian , Shao, Jingwei , Ding, Donglin , Pan, Yunqian , Tran, Phuc , Li, Hongyu , Huang, Haojie , Huang, Rui , Yan, Wei , Wang, Zhenyu
Chemical Communications | January 26, 2022 | Volume: 58 | Issue: 14 | Pages: 2383-2386
In this study, we discovered 3-aminophthalic acid as a new ligand of cereblon (CRBN) E3 ubiquitin ligase and developed a phthalic acid-based O’PROTAC for ERG destruction, expanding the pool of ligands for development of PROTACs, especially O’PROTACs.