Citations 1
Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality
Pidala, Joseph, Wang, Tao , Haagenson, Michael , Askar, Medhat , Baxter‐Lowe, Lee Ann , Bitan, Menachem, Fernández-Viña, Marcelo , Jakubowski, Ann A. , Maiers, Martin , Marino, Susana R. , Oudshoorn, Machteld, Palmer, Jeanne , Prasad, Vinod K. , Reddy, Vijay , Ringdén, Olle , Saber, Wael , Santarone, Stella , Schultz, Kirk R. , Setterholm, Michelle, Trachtenberg, Elizabeth, Turner, E. Victoria, Woolfrey, Ann E. , Lee, Stephanie J. , Anasetti, Claudio , Spellman, Stephen R. , Battiwalla, Minoo , Gandhi, Manish J. , Marsh, Steven G. E. , Ringden, Olov , Lee, Stephanie J , Maiers, Martin
Blood | August 28, 2013 | Volume: 122 | Issue: 22 | Pages: 3651-3658
Key PointsAmino acid substitution at peptide-binding residues of the HLA class I molecule is associated with graft-versus-host disease and mortality. Avoidance of donor-recipient combinations that result in amino acid substitution at peptide-binding residues may improve transplant outcomes.