Citations 2
Risk factors for development of long-term mood and anxiety disorder after pediatric traumatic brain injury: a population-based, birth cohort analysis
Esterov, Dmitry , Witkowski, Julie, McCall, Dana M., Weaver, Amy L. , Brown, Allen W. , Esterov, Dmitry , McCall, Dana M. , Wi, ChungâIl
Brain Injury | May 23, 2022 | Volume: 36 | Issue: 6 | Pages: 722-732
Neuropsychological Functioning in Alexander Disease: A Case Series
Kirsch, Alexandra C. , McCall, Dana M., Lange, Hadley, Renaud, Deborah L. , Brown, Tanya M. , Zaccariello, Michael J. , Renaud, Deborah , Brown, Tanya, McCall, Dana M.
Child Neurology Open | October 20, 2021 | Volume: 8 | Issue: No issue available | Pages: No page available
Limited information is known about neuropsychological outcomes in Alexander disease, a rare leukodystrophy. Two pediatric cases are summarized. Case 1 (evaluations at 6, 7, 9, and 12 years of age) represents Type I Alexander disease with associated seizures. Case 2 (evaluations at 12, 13, and 16 years of age) represents Type II Alexander disease without additional complications. Case 1 experienced declines in intellectual functioning, visual motor skills, receptive vocabulary, verbal memory, and academic achievement. Case 2 experienced variable neurocognitive change and academic functioning, with average word reading and spelling. Verbal memory also remained intact. Taken together, individuals with Alexander disease may experience cognitive decline to variable degrees. Type I Alexander disease, associated with earlier onset and additional neurological complications, may presage greater cognitive decline than Type II. Due to variability in functioning over time, it is critical to follow individuals across development to make recommendations for educational and treatment planning.