Citations 1
Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase
Pashkova, Natalya, Yu, Liping, Schnicker, Nicholas J., Tseng, Chun-Che, Gakhar, Lokesh, Katzmann, David J., Piper, Robert C., Piper, Robert C. , Pashkova, Natalya , Piper, Robert C , Yu, Liping, Schnicker, Nicholas , Tseng, Chun-Che, Gakhar, Lokesh, Katzmann, David J.
Molecular Biology of the Cell | September 29, 2021 | Volume: 32 | Issue: 22 | Pages: No page available
Structural studies reveal that the V domain of HD-PTP has two tandem binding sites for binding ubiquitin. Like its yeast counterpart Bro1, HD-PTP binds the Vps4 MIT domain, stimulating its activity in a manner that is augmented by ubiquitin binding.