Citations 1
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer
Aggarwal, Ritesh K. , Luchtel, Rebecca A. , Machha, Venkata R. , Tischer, Alexander , Zou, Yiyu , Ashai, Nadia , Ramachandra, Nandini , Albanese, Joseph , Yang, Jung‐In , Aluri, Srinivas , Gordon, Shanisha, Aboumohamed, Ahmed , Gartrell, Benjamin A. , Hafizi, Sassan , Pullman, James , Shenoy, Niraj , Yang, Jung-In , Aluri, Srinivas , Aboumohamed, Ahmed , Hafizi, Sassan , Shenoy, Niraj , Tischer, Alexander , Pradhan, Kith , Wang, Xiaoyang
Proceedings of the National Academy of Sciences | September 22, 2021 | Volume: 118 | Issue: 39 | Pages: No page available
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation of oncogenic succinate is a common, adverse, epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), during pathogenesis and progression. The study sheds light on the mechanisms of down-regulation of SDH subunits in ccRCC and deciphers the consequent oncogenic effects. It shows that functional SDH deficiency is a common feature of ccRCC (∼80% of all kidney cancers), and not just limited to the 0.05 to 0.5% of kidney cancers with germline SDH mutations.