Citations 1
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes
Malinge, Sébastien , Chlon, Timothy M. , Doré, Louis C. , Ketterling, Rhett P. , Tallman, Martin S. , Paietta, Elisabeth , Gamis, Alan S. , Weiss, Mitchell J. , Crispino, John D. , Figueroa, María E. , Chlon, Timothy M. , Taub, Jeffrey Warren , Chou, Stella T. , Crispino, John D , Ketterling, Rhett P
Blood | August 27, 2013 | Volume: 122 | Issue: 14 | Pages: e33-e43
Key PointsDNA methylation changes during the development of DS-AMKL occur in sequential waves of opposing losses and gains of methylation. Each wave of DNA methylation abnormalities targets specific gene networks that contribute to distinct biological features of the disease.