Citations 1
It's in the Eye of the Beholder: Ocular Ultrasound Enhanced Monitoring of Neurotoxicity after CAR T-cell therapy
García-Robledo, Juan Esteban , Knox, Molly G., Goodman, Brent P., Garcia-Robledo, Juan Esteban , Valencia-Sánchez, Cristina , Rosenthal, Allison , Castro, Januario E. , Patel, Bhavesh
No container title available | September 14, 2021 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Usually used in emergency settings, bedside sonographic measurement of optic nerve sheath diameter can aid in diagnosing elevated intracranial pressure. We report a case of a 26-year-old male hospitalized for CAR T-cell therapy with Axicabtagene Ciloleucel for treatment of relapsed diffuse large B-cell lymphoma, who developed progressive symptoms of immune effector cell-associated neurotoxicity syndrome. Fundoscopic examination suggested the presence of blurred optic disc margins. Bedside ocular ultrasound revealed wide optic nerve sheath diameters and bulging optic discs bilaterally. The patient had a ventriculostomy placed for monitoring and received treatment with steroids and mannitol, as well as tocilizumab. After 7 days in the ICU, the patient recovered with no evidence of long-term neurological deficits.