Citations 1
Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking
Burton, Kevin M., Johnson, Katherine M. , Krueger, Eugene W. , Razidlo, Gina L. , McNiven, Mark A. , Razidlo, Gina L , Burton, Kevin M., Johnson, Katherine M.
Molecular Biology of the Cell | May 19, 2021 | Volume: 32 | Issue: 15 | Pages: 1393-1407
Macropinocytosis is an essential mechanism by which pancreatic tumor cells internalize extracellular material to be used as an energy source to fuel proliferation. We describe the mechanism by which the actin cross-linking α-actinin proteins mediate membrane ruffling and macropinosome delivery to the lysosome during this process.