Citations 2
Author response: MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
Codreanu, Simona G. , Thomas, Lance R. , Lorey, Shelly L. , Machida, Yuichi , Popay, Tessa M. , Wang, Jing , Adams, Clare M. , Howard, Gregory C. , Sherrod, Stacy D. , McLean, John A. , Weissmiller, April M. , Eischen, Christine M. , Liu, Qi , Tansey, William P
No container title available | January 8, 2021 | Volume: No volume available | Issue: No issue available | Pages: No page available
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
Popay, Tessa M. , Howard, Gregory C. , Codreanu, Simona G. , Sherrod, Stacy D. , McLean, John A. , Thomas, Lance R. , Lorey, Shelly L. , Machida, Yuichi , Weissmiller, April M. , Eischen, Christine M. , Sherrod, Stacy D , Machida, Yuichi J, Eischen, Christine M , Tansey, William P , Wang, Jing , Adams, Clare M. , Liu, Qi
eLife | January 8, 2021 | Volume: 10 | Issue: No issue available | Pages: No page available
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we interrogate how one MYC co-factor, host cell factor (HCF)–1, contributes to MYC activity in a human Burkitt lymphoma setting. We identify genes connected to mitochondrial function and ribosome biogenesis as direct MYC/HCF-1 targets and demonstrate how modulation of the MYC–HCF-1 interaction influences cell growth, metabolite profiles, global gene expression patterns, and tumor growth in vivo. This work defines HCF-1 as a critical MYC co-factor, places the MYC–HCF-1 interaction in biological context, and highlights HCF-1 as a focal point for development of novel anti-MYC therapies.