Citations 1
Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Whitmire, Paula , Rickertsen, Cassandra , Lorence, Julia, León, Gustavo De , Bayless, Spencer, Clark-Swanson, Kamala , Corpuz, Christina, Angeles, Christine Paula Lewis-de los, Vora, Sujay A., Mrugała, Maciej M. , Hu, Leland , Porter, Alyx B. , Kumthekar, Priya , Johnston, Sandra K. , Egan, Kathleen M. , Canoll, Peter , Swanson, Kristin R. , Swanson, Kristin R , Hawkins‐Daarud, Andrea , Carrasco, Eduardo, Curtin, Lee , Peeri, Noah Charles , Bendok, Bernard R. , Gonzalez‐Cuyar, Luis F. , Wang, Lei G. , Gatenby, Robert A. , Rubin, Joshua B
No container title available | January 27, 2020 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Background : Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods : Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results : Among males, tumor (T1Gd) radius was a predictor of overall survival (HR=1.027, p=0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR=1.011, p<0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p=0.010 t-test), but tumor size was not correlated with female overall survival (p=0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p=0.004, F p=0.001, t-test). Conclusion : Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.