Citations 1
Costimulation of  T cells by B7-H2, a B7-like molecule that binds ICOS
Wang, Shengdian , Zhu, Gefeng, Chapoval, Andrei I. , Tamada, Koji , Dong, Haidong , Ni, Jian, Chen, Lieping
Blood | October 13, 2019 | Volume: 96 | Issue: 8 | Pages: 2808-2813
Abstract This report describes a new human B7-like gene designatedB7-H2. Cell surface expression of B7-H2 protein is detected in monocyte-derived immature dendritic cells. Soluble B7-H2 and immunoglobulin (Ig) fusion protein, B7-H2Ig, binds activated but not resting T cells and the binding is abrogated by inducible costimulator Ig (ICOSIg), but not CTLA4Ig. In addition, ICOSIg stains Chinese hamster ovary cells transfected with B7-H2 gene. By suboptimal cross-linking of CD3, costimulation of T-cell proliferation by B7-H2Ig is dose-dependent and correlates with secretion of interleukin (IL)-2, whereas optimal CD3 ligation preferentially stimulates IL-10 production. The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule.