Citations 1
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms
Hinds, David A. , Barnholt, Kimberly E., Kiefer, Amy K. , Do, Chuong B., Eriksson, Nicholas , Mountain, Joanna L. , Francke, Uta, Tung, Joyce Y., Nguyen, Huong , Zhang, Haiyu , Gojenola, Linda, Zehnder, James L. , Mesa, Ruben A. , Do, Chuong B., Tung, Joyce Y. , Gotlib, Jason
Blood | June 30, 2016 | Volume: 128 | Issue: 8 | Pages: 1121-1128
Key Points Germ line variants in TERT, SH2B3, TET2, ATM, CHEK2, PINT, and GFI1B are associated with JAK2 V617F clonal hematopoiesis and MPNs. Age-related JAK2 V617F clonal hematopoiesis is found in ∼2 out of 1000 individuals in the general population.