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Crum, Braydon A

Mayo Clinic

Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.

Citations 1

TrkB signaling modulates neuromuscular transmission in a frequency-dependent manner in the mouse diaphragm muscle
Crum, Braydon, Martinez, Robert C , Jahanian, Sepideh , Sieck, Gary C. , Mantilla, Carlos B. , Crum, Braydon A, Gransee, Heather M , Sieck, Gary , Mantilla, Carlos B , Martinez, R C , Gransee, Heather M.

Journal of Neurophysiology | August 7, 2026 | Volume: 136 | Issue: 3 | Pages: 959-968

10.1152/jn.00276.2026 Get It

This study found that inhibiting TrkB kinase activity decreases the extent of neuromuscular transmission failure during repetitive stimulation at low frequency while increasing failure with high-frequency stimulation. The frequency-dependent effect of 1NMPP1 treatment suggests that the role of TrkB signaling in maintaining neuromuscular transmission during repetitive stimulation may differ between motor unit types (slow-twitch, fatigue-resistant vs. fast-twitch, fatigable) and likely reflect effects at the presynaptic terminal without major effects on the muscle itself.