Citations 2
APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Liu, Chia‐Chen , Murray, Melissa E. , Li, Xia , Zhao, Na , Wang, Na , Shue, Francis , Martens, Yuka A. , Li, Yonghe , Raulin, Ana‐Caroline , Rosenberg, Cassandra L. , Doss, Sydney V. , Wren, Melissa C. , Jia, Lin , Ren, Yingxue , Ikezu, Tadafumi C. , Lü, Wenyan, Trottier, Zachary A. , Chen, Yixing , Linares, Cynthia , Wang, Xue , Kurti, Aishe, Asmann, Yan W. , Vemuri, Prashanthi , Kantarci, Kejal , Lowe, Val J. , Jack, Clifford R. , Parisi, Joseph E., Ferman, Tanis J. , Graff‐Radford, Neill R. , Petersen, Ronald C. , Younkin, Steven G. , Fryer, John Denis , Frieden, Carl , Ross, Owen A. , Bu, Guojun , Shue, Francis , Atagi, Yuka , Raulin, Ana-Caroline , Doss, Sydney V , Zhao, Jing , Wren, Melissa C , Ikezu, Tadafumi C , Caulfield, Thomas R , Trottier, Zachary A , Wszolek, Z.K. , Smith, Glenn E. , Vemuri, Prashanthi , Jack, Clifford R , Ferman, Tanis J , Boeve, Brad , Petersen, Ronald C , Younkin, Steven , Frieden, Carl , Dickson, Dennis W , Ross, Owen A , Bu, Guojun , Liu, Chia-Chen , Kantarci, Kejal , Murray, Melissa E , Zhao, Na , Chen, Yixing , Heckman, Michael G. , Zhao, Jing , Fu, Yuan , Caulfield, Thomas R. , Knight, Joshua A. , Wszołek, Zbigniew K. , Knopman, David S. , Boeve, Bradley F. , Wang, Hu , Han, Xianlin , Dickson, Dennis W.
Science Translational Medicine | September 29, 2021 | Volume: 13 | Issue: 613 | Pages: No page available
A rare APOE variant APOE3 -Jac reduces self-aggregation and promotes healthy brain aging.
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
Verghese, Philip B. , Castellano, Joseph M. , Garai, Kanchan , Jiang, Hong , Shah, Aarti R., Bu, Guojun , Frieden, Carl , Wang, Yinong , Holtzman, David M. , Bu, Guojun
Proceedings of the National Academy of Sciences | April 26, 2013 | Volume: 110 | Issue: 19 | Pages: No page available
Significance It has been proposed that differential physical interactions of apolipoprotein E (apoE) isoforms with soluble amyloid-β (Aβ) in brain fluids influence the metabolism of Aβ, providing a major mechanism to account for how APOE influences Alzheimer’s disease risk. The current study challenges this proposal and clearly shows that lipoproteins containing apoE isoforms are unlikely to play a significant role in Aβ metabolism by binding directly to Aβ in physiological fluids such as cerebrospinal fluid or interstitial fluid. Our in vitro and in vivo results suggest that apoE isoforms influence Aβ metabolism by competing for the same clearance pathways within the brain.