Wilking, James N
Mayo Clinic
Department of Chemical and Biological Engineering, Montana State University, Bozeman, Montana, United States.
Citations 1
Physical, chemical, and structural properties of human gastric organoid-derived mucus
Lyon, Katrina , Sidar, Barkan , Gattiker, Jasper , Dudiak, Cameron, Vermulm, Chloe, Jordan, Grace, Sebrell, Thomas A., Morris, Maeve T., Tabone, Lawrence , Szoka, Nova, Abunnaja, Salim , Boone, Brian A., Burcham, Alexis , Domanico, Luke F. , Liao, Wentian, Davis, Bret H., Wilking, James N. , Bansil, Rama, Lyon, Katrina N , Busada, Jonathan T , Helm, Richard F , Davis, Bret , Brown, Jennifer , Wilking, James N , Bansil, Rama , Bimczok, Diane , Gattiker, Jasper , Dudiak, Cameron, Jordan, Grace, Sebrell, Thomas A., Morris, Maeve T., Tabone, Lawrence , Szoka, Nova, Abunnaja, Salim , Boone, Brian A., Brown, Jennifer L. , McCalla, Scott G.
American Journal of Physiology-Gastrointestinal and Liver Physiology | July 16, 2026 | Volume: 331 | Issue: 2 | Pages: G244-G261
We demonstrate the structural and functional similarities of organoid-derived gastric mucus and native mucus collected from human patients. The bioengineered gastric mucus mimics its native counterpart in its proteomic profile and physical architecture. This work highlights the translational potential of organoid-derived mucus for functional investigations of the human gastric mucus layer.