Citations 11
Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL
Vardi, Anna , Dagklis, Antonis, Scarfò, Lydia , Jelinek, Diane F., Newton, Darren , Bennett, Fiona, Rodríguez‐Caballero, Arancha, Allgood, Sallie D. , Lanasa, Mark C., Cortelezzi, Agostino , Orlandi, Ester , Veronese, Silvio , Montillo, Marco , Rawstron, Andy C. , Σταματόπουλος, Κώστας , Ghia, Paolo , Almeida, Júlia , Shanafelt, Tait D. , Órfão, Alberto , Ghia, Paolo , Newton, Darren J
Blood | April 18, 2013 | Volume: 121 | Issue: 22 | Pages: 4521-4528
Key Points Low-count and high-count monoclonal B-cell lymphocytosis (MBL) have distinct immunogenetic signatures, with only the latter resembling CLL. Rather than a true premalignant condition, low-count MBL may merely reflect immune senescence or result from persistent antigen stimulation.