Citations 2
International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease
Barbara, Pascal de Santa , Lorenzo, Carlo Di, Alves, Maria M. , Beyder, Arthur, Borrelli, Osvaldo, Cacopardo, Ludovica , Ceron, Rachel, Contessa, Antonio, Giorgio, Roberto De, Diamanti, Antonella , Faticato, Maria Grazia, Hashmi, Sohaib K., Huizinga, Jan D. , Kapur, Raj P. , Lambe, Cécile, Lancon, Laurence, McManigal, Ryan, Palmitelli, Alessandro, Perreaux, Victor , Pitto, Michela, Proietti, Elisa, Rendu, John , Rybak, Anna, Sardar, Sabah , Stanghellini, V, Tambucci, Renato , Berghe, Pieter Vanden , Wang, Qianqian, Wangler, Michael, Wolfson, Sharon, Zada, Almira , Cacopardo, Ludovica , Perreaux, Victor , Pitto, Michela , Sanders, Kenton M , Vanden Berghe, Pieter , Wolfson, Sharon , Zada, Almira , Viti, Federica , Ceccherini, Isabella , Heuckeroth, Robert O. , Beyder, Arthur , Borrelli, Osvaldo , Ceron, Rachel H. , Chen, Jihong , Chiappori, Federica , Giorgio, Roberto De , Faure, Sandrine, Lambe, Cécile , Mousa, Hayat M. , Prato, Alessio Pini , PROIETTI, ELISA, Rybak, Anna , Thapar, Nikhil , Vassalli, Massimo , Wangler, Michael F , Zhou, Jiliang
Neurogastroenterology & Motility | April 15, 2026 | Volume: 38 | Issue: 4 | Pages: No page available
ABSTRACT Background Visceral myopathy (VSCM) is an ultra‐rare life‐threatening condition characterized by severe impairment of gastrointestinal (GI), genitourinary, and uterine smooth muscle. This disorder represents a significant clinical challenge due to variable presentation and the lack of standardized diagnostic and therapeutic protocols. Methods To discuss advances in the field, scientists and clinicians with a special interest in VSCM met in Arenzano, Genova, Italy in October 2024 for the second International Forum on Visceral Myopathy 2024 (IFVM2024) ( https://ifvm2024.ge.ibf.cnr.it/ ). Key Results As in the previous edition of the event ( https://poic‐e‐dintorni.org/efvm‐2022/ ), attendees included clinicians and researchers from around the world who study this disease, representatives from support organizations, patients affected by VSCM and their families, and companies that co‐funded the event. The present manuscript aims to summarize knowledge shared during the IFVM2024 conference, thus providing an updated state‐of‐the‐art summary of VSCM biology and disease management. Conclusions Here, we pay particular attention to the epidemiology of the disease, histopathology, genetics, novel treatments, advances in molecular and cell biology, experimental models, and the lived experiences and impact of this disorder on families.
Overview of the Enteric Nervous System
Mawe, Gary M. , Camilleri, Michael , Sanders, Kenton M
Seminars in Neurology | August 10, 2023 | Volume: 43 | Issue: 04 | Pages: 495-505
AbstractPropulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory neurons, pacemaker cells such as the interstitial cells of Cajal and fibroblast-like cells, and smooth muscle cells. Coordination between these extrinsic and enteric neurons results in propulsive functions which include peristaltic reflexes, migrating motor complexes in the small intestine which serve as the housekeeper propelling to the colon the residual content after digestion, and mass movements in the colon which lead to defecation.