Cunningham, Brian T
Mayo Clinic
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. seemeshb@illinois.edu.
Citations 2
Point of care molecular cancer diagnostics
Bhaskar, Seemesh , Umrao, Saurabh , Lee, Han Keun , Tibbs, Joseph , Bacon, Amanda , Shepherd, Skye , Ayupova, Takhmina , Ciloglu, Fatma Uysal , Liu, Leyang , Tan, Anqi , Chen, Wang-Chien , Nguyen, My Thi Tra , Scannell, Maria Grace , Aygün, Uğur , Zhang, Catherine, Adami, Guy R. , Badar, Wali, Gaba, Ron C. , Mansfield, A., Schwartz, Joel L., XING, WANG, Demirci, Utkan, Parlatan, Ugur , Zhang, Catherine , Kohli, Manish , Adami, Guy R , Badar, Wali , Gaba, Ron C , Mansfield, Aaron S , Schwartz, Joel , Xing, Wang , Demirci, Utkan , Cunningham, Brian T , Kohli, Manish , Mansfield, Aaron S. , Demirci, Utkan , Cunningham, Brian T.
Lab on a Chip | February 10, 2026 | Volume: 26 | Issue: 10 | Pages: 2948-3001
Convergent framework for future POC cancer diagnostics aligning clinical needs (why), enabling technologies (how), and translational bridges. It integrates lab-on-chip biosensing and analytics for decentralized, early, longitudinal care.
Digital-resolution detection of microRNA with single-base selectivity by photonic resonator absorption microscopy
Canady, Taylor D., Li, Nantao , Smith, Lucas D. , Lu, Yi , Smith, Andrew M. , Cunningham, Brian T. , Kohli, Manish , Smith, A M , Cunningham, Brian T
Proceedings of the National Academy of Sciences | September 9, 2019 | Volume: 116 | Issue: 39 | Pages: 19362-19367
Significance Highly selective and sensitive detection of microRNA is a key challenge in the development of liquid-biopsy approaches. Technologies that can achieve high diagnostic performance without the requirement of complicated processing steps or expensive equipment are necessary for broad use. With these features in mind, we demonstrate a digital-readout microRNA diagnostic that fundamentally relies on microRNA-activated nanoparticle-photonic crystal hybrid coupling. The hybrid formation allows for clear detection of single-particle binding events due to enhanced nanoparticle absorption at the binding location. Whereas the applied photonics lend the assay concentration sensitivity, we additionally demonstrate broad placement single-base mismatch selectivity and complex media detection by applying free-energy tuned toehold probes.