Iannarelli, Nathaniel J
Mayo Clinic
Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Citations 1
The role of α 2 -adrenergic mechanisms in sympathetic baroreflex control of human blood pressure
Spafford, Julia, Limberg, Jacqueline K. , Wiggins, Chad C. , Iannarelli, Nathaniel , Senefeld, Jonathon W. , Nicholson, Wayne T. , Shoemaker, J. Kevin , Spafford, Julia E , Harvey, Ronée E , Wiggins, Chad C , Iannarelli, Nathaniel J , Senefeld, Jonathon W , Curry, Timothy B. , Joyner, Michael J , Shoemaker, J Kevin , Baker, Sarah E , Klassen, Stephen A , Harvey, Ronée E. , Joyner, Michael J. , Baker, Sarah E. , Klassen, Stephen A.
American Journal of Physiology-Heart and Circulatory Physiology | September 3, 2025 | Volume: 329 | Issue: 5 | Pages: H1229-H1243
Intravenous dexmedetomidine infusion (selective α 2 -adrenergic receptor agonist) 1) reduced the firing probability and strength of baroreflex control over medium-sized sympathetic action potentials in muscle sympathetic nerve activity (MSNA) and 2) attenuated the transduction of MSNA bursts to changes in blood pressure (BP) by reducing the magnitude of BP responses and increasing the time to peak BP. These data suggest that neural and vascular α 2 -adrenergic mechanisms contribute to sympathetic baroreflex regulation of human BP.