Calixto Mancipe, Natalia
Mayo Clinic
Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States.
Citations 1
Role of long-chain acyl-CoA synthetases in MASH-driven hepatocellular carcinoma and ferroptosis
Classon, Peyton, Wixom, Alexander Q. , Mancipe, Natalia Calixto , Taner, Timuçin , Povero, Davide , Calixto Mancipe, Natalia , Tran, Nguyen , Povero, Davide , Wixom, Alexander Q , Graham, Rondell P. , Zhao, Yu , Tran, Nguyen H.
American Journal of Physiology-Gastrointestinal and Liver Physiology | August 28, 2025 | Volume: 329 | Issue: 5 | Pages: G571-G584
Our study examined healthy human MASH and MASH-associated hepatocellular carcinoma (MASH-HCC) livers using bulk and scRNA sequencing, spatial transcriptomics, and immunohistochemistry. We found that ACSLs displayed differential and spatially heterogeneous expression. ACSL4 was abundant in tumor tissues, whereas ACSL5 was elevated in noncancerous MASH tissues. ACSL4 was mainly found in immune cells like natural killer cells and natural killer T cells in murine MASH-HCC, suggesting its role in tumor immune microenvironment modulation.