Citations 1
Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium
Klatt, Emily, Hamdan, Feda H. , Pérez, Isaiah , Kossick, Kimberlee , Fedyshyn, Yaroslav , Sagstetter, Mary R., Chiang, David , Chini, Lucas C. S., Davidson, H, Westphal, Maria S., Gades, Naomi M. , Mopuri, Rohini , Druliner, Brooke R. , Faubion, William A. , Klatt, Emily E, Smith, Hannah M , Kossick, Kimberlee , Davidson, Heidi M, Bamidele, Adebowale O , Druliner, Brooke , Chini, Lucas C. S., Sun, Zhifu , Bamidele, Adebowale O.
American Journal of Physiology-Gastrointestinal and Liver Physiology | August 18, 2025 | Volume: 329 | Issue: 6 | Pages: G696-G707
This study reveals a novel role for Treg-derived IL-6R in supporting epithelial repair. Despite preserved immune-suppressive capacity, deletion of IL-6R from Tregs impairs epithelial transcription and worsens injury in colitis. We demonstrate that human intestinal organoids preferentially respond to trans- over classic IL-6 signaling. These findings introduce a Treg-specific role in immune-epithelial cross talk relevant to mucosal healing and inflammatory bowel disease.