Citations 1
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation
Tiraplegui, Carolina, Garaikoetxea, Mattie , Sádaba, Alba de, Ildefonso-García, Susana San, Goñi-Olóriz, Miriam , Martín‐Núñez, Ernesto , Álvarez, Virginia , Sádaba, Rafael , Anand, Vidhu , López‐Andrés, Natalia , Fernández-Celis, Amaya , Martín-Núñez, Ernesto , Sádaba, Rafael , Jover, Eva , López-Andrés, Natalia , Sádaba, Alba, Navarro, Adela
American Journal of Physiology-Heart and Circulatory Physiology | January 13, 2025 | Volume: 328 | Issue: 3 | Pages: H693-H710
The pathogenesis of chronic aortic regurgitation (AR) is different in male and female. Female patients with AR showed less aortic valve inflammation and collagen accumulation as compared with male. Valvular cells from female patients secreted less inflammatory molecules and collagen and higher levels of proteoglycans. Valvular interstitial cells from females were more sensitive to transforming growth factor (TGF)-β-induced proteoglycans secretion. Our study opens a new perspective oriented toward sex-specific molecular pathways and therapeutic targets in chronic severe AR.