Citations 6
Safety and Efficacy of Satralizumab in Patients with Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): Results from the Phase 3 METEOROID Trial (PL5.006)
Levy, Michael, Flanagan, Eoin , Kümpfel, Tania, Marignier, Romain, Fujihara, Kazuo, Hemingway, Cheryl, Stokmaier, Daniela, Klingelschmitt, Gaëlle, Büdingen, H.-Christian von, TANAKA, SAYURI, Friedemann, Paul, Levy, Michael , Flanagan, Eoin P. , Kümpfel, Tania , Marignier, Romain , Fujihara, Kazuo , Hemingway, Cheryl , Büdingen, H.-Christian von, Li, Li
Neurology | June 10, 2026 | Volume: 106 | Issue: 11_Supplement_1 | Pages: No page available
Investigating the Frequency and Outcome of Central Vein Sign and Paramagnetic Rim Lesions in Children With MOGAD
Nistri, Riccardo , Cacciaguerra, Laura , Sacco, Simone , Virupakshaiah, Akash , Meo, Ermelinda De , Papinutto, Nico , Henry, Roland, Meirson, Hadas , Bensira, Liat, Pratt, Li-tal, Biswas, Asthik, Mankad, Kshitij , Chen, John J., Pittock, S J , Barkhof, Frederik , Ciccarelli, Olga, Waubant, Emmanuelle, Ciccarelli, Olga , De Meo, Ermelinda , Henry, Roland G , Hemingway, Cheryl , Rossor, Thomas , Wassmer, Evangeline , Biswas, Asthik , Sudhakar, Sniya , Mankad, Kshitij , Chen, John J , Barkhof, Frederik , Ciccarelli, Olga , Waubant, Emmanuelle L. , Flanagan, E P , Hacohen, Yael , Cacciaguerra, Laura , Virupakshaiah, Akash , Henry, Roland G. , Wassmer, Evangeline , Ben‐Sira, Liat , Pratt, Li‐tal , Flanagan, Eoin P. , Hacohen, Yael
Neurology | January 9, 2026 | Volume: 106 | Issue: 3 | Pages: No page available
Differential Diagnosis of Suspected Multiple Sclerosis in Pediatric and Late-Onset Populations
Hua, Le H. , Solomon, Andrew , Tenembaum, Sílvia , Rostásy, Kevin , Newsome, Scott D. , Marrie, Ruth Ann , Magyari, Melinda , Kantarci, Orhun H. , Cohen, Jeffrey A., Bove, Riley , Banwell, Brenda , Magyari, Melinda , Scalfari, Antonio , Rovira, Àlex , Hemmer, Bernhard , Hemingway, Cheryl , Harnegie, Mary Pat , Graves, Jennifer , Corboy, John R. , Waubant, Emmanuelle L.
JAMA Neurology | September 16, 2024 | Volume: 81 | Issue: 11 | Pages: 1210
Importance While the typical onset of multiple sclerosis (MS) occurs in early adulthood, 2% to 10% of cases initially present prior to age 18 years, and approximately 5% after age 50 years. Guidance on approaches to differential diagnosis in suspected MS specific to these 2 age groups is needed. Observations There are unique biological factors in children younger than 18 years and in adults older than age 50 years compared to typical adult-onset MS. These biological differences, particularly immunological and hormonal, may influence the clinical presentation of MS, resilience to neuronal injury, and differential diagnosis. While mimics of MS at the typical age at onset have been described, a comprehensive approach focused on the younger and older ends of the age spectrum has not been previously published. Conclusions and Relevance An international committee of MS experts in pediatric and adult MS was formed to provide consensus guidance on diagnostic approaches and key clinical and paraclinical red flags for non-MS diagnosis in children and older adults.
Radiologic Lag and Brain MRI Lesion Dynamics During Attacks in MOG Antibody–Associated Disease
Cacciaguerra, Laura , Abdel‐Mannan, Omar , Champsas, Dimitrios , Mankad, Kshitij , Krecke, Karl N. , Chen, John J. , Redenbaugh, Vyanka , López‐Chiriboga, A. Sebastian , Valencia-Sánchez, Cristina , Tillema, Jan‐Mendelt , Ciccarelli, Olga , Pittock, Sean J. , Pittock, S J , Syc-Mazurek, Stephanie B , Redenbaugh, Vyanka , Lopez-Chiriboga, Alfonso S, Valencia Sanchez, Cristina , Hemingway, Cheryl , Ciccarelli, Olga , Hacohen, Yael , Flanagan, E P , Chen, John J , Cacciaguerra, Laura , Champsas, Dimitrios , Syc‐Mazurek, Stephanie B. , Hacohen, Yael , Flanagan, Eoin P.
Neurology | May 6, 2024 | Volume: 102 | Issue: 10 | Pages: No page available
Investigating Radiological Lag and the Temporal Evolution of MRI Lesions Within the Same Attack in MOGAD (S32.008)
Mankad, Kshitij , Krecke, Karl N. , Chen, John , Redenbaugh, Vyanka , Lopez, Alfonso, Sánchez, Cristina Valencia, Tillema, Jan‐Mendelt , Cacciaguerra, Laura , Abdel‐Mannan, Omar , Champsas, Dimitrios , Syc‐Mazurek, Stephanie B. , Hemingway, Cheryl , Ciccarelli, Olga , Pittock, Sean J. , Hacohen, Yael , Flanagan, Eoin P.
Neurology | April 9, 2024 | Volume: 102 | Issue: 7_supplement_1 | Pages: No page available
Do Early Relapses Predict the Risk of Long‐Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD ?
Chen, Bo , Gómez‐Figueroa, Enrique , Redenbaugh, Vyanka , Satukijchai, Chanjira , Messina, Silvia , Sá, Mário , Woodhall, Mark , Paul, Friedemann , Robertson, Neil P. , Lim, Ming , Wassmer, Evangeline , Kneen, Rachel , Huda, Saif , Blain, Camilla, Halfpenny, Christopher , O’Sullivan, Eoin , Hobart, Jeremy , Fisniku, Leonora , Martin, Roswell , Cooper, Sarah , Williams, Victoria , Chen, John J. , Pittock, Sean J. , Ramdas, Sithara , Leite, Maria Isabel , Geraldes, Ruth , Palace, Jacqueline , Pittock, S J , Messina, Silvia , Sa, Mario , Lim, Ming , Dobson, Ruth , Chen, John J , Paul, Friedemann , Geraldes, Ruth , Palace, Jacqueline , Wassmer, Evangeline , Francis, Anna G. , Wu, Yan Ting , Hemingway, Cheryl , Williams, Victoria, Waters, Patrick , Flanagan, Eoin P.
Annals of Neurology | July 3, 2023 | Volume: 94 | Issue: 3 | Pages: 508-517
Objective Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can be monophasic or relapsing, with early relapse being a feature. However, the relevance of early relapse on longer‐term relapse risk is unknown. Here, we investigate whether early relapses increase longer‐term relapse risk in patients with MOGAD. Methods A retrospective analysis of 289 adult‐ and pediatric‐onset patients with MOGAD followed for at least 2 years in 6 specialized referral centers. “Early relapses” were defined as attacks within the first 12 months from onset, with “very early relapses” defined within 30 to 90 days from onset and “delayed early relapses” defined within 90 to 365 days. “Long‐term relapses” were defined as relapses beyond 12 months. Cox regression modeling and Kaplan–Meier survival analysis were used to estimate the long‐term relapse risk and rate. Results Sixty‐seven patients (23.2%) had early relapses with a median number of 1 event. Univariate analysis revealed an elevated risk for long‐term relapses if any “early relapses” were present (hazard ratio [HR] = 2.11, p < 0.001), whether occurring during the first 3 months (HR = 2.70, p < 0.001) or the remaining 9 months (HR = 1.88, p = 0.001), with similar results yielded in the multivariate analysis. In children with onset below aged 12 years, only delayed early relapses were associated with an increased risk of long‐term relapses (HR = 2.64, p = 0.026). Interpretation The presence of very early relapses and delayed early relapses within 12 months of onset in patients with MOGAD increases the risk of long‐term relapsing disease, whereas a relapse within 90 days appears not to indicate a chronic inflammatory process in young pediatric‐onset disease. ANN NEUROL 2023;94:508–517