Morais, José A
Mayo Clinic
Department of Medicine, McGill University and Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Citations 2
Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions
Hajj‐Boutros, Guy , Faust, Andréa, Kim, Perry, Chevalier, Stéphanie , Bergman, Howard , Burford, Jessica S , Carrington‐Lawrence, Stacy, Côté, Hélène, Fowler, Robert , Gouspillou, Gilles , Harrington, Lea , Imani, Mahdi , Kirkland, James L. , Mallette, Frédérick A. , Newman, John C. , Pullman, Daryl , Sierra, Felipe , Rylett, R. Jane , Duque, Gustavo , Chevalier, Stéphanie , Farrelly, Colin , Lautrup, Sofie , Howlett, Susan , Kirkland, James, Morais, José A , Newman, John C , Van Raamsdonk, Jeremy , Watt, Jennifer , Duque, Gustavo , Muscedere, John , Abumrad, Naji N. , Aubertin‐Leheudre, Mylène , Bowdish, Dawn M. E. , Dawe, David E. , Barreto, Philipe de Souto , Howlett, Susan E. , Kuchel, George A. , Morais, José A.
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | March 15, 2024 | Volume: 79 | Issue: 7 | Pages: No page available
Abstract The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience, and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic determinants of aging, and prevention of chronic disease were addressed, the conferences went on to emphasize practical applications for enhancing older people’s quality of life. This article summarizes the proceeding and underscores the synergy between clinical and fundamental studies. Future directions highlight national and global collaborations and the crucial integration of early-career investigators. This work charts a course for a national framework for continued innovation and advancement in translational geroscience in Canada.
Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss
Murphy, Jessica , Tam, Bjorn T. , Kirkland, James L. , Tchkonia, Tamar , Giorgadze, Nino, Pirtskhalava, Tamar , Tsoukas, Michael A. , Morais, José A. , Santosa, Sylvia , Tchkonia, T , Morais, José A
Obesity | May 17, 2023 | Volume: 31 | Issue: 6 | Pages: 1610-1619
AbstractObjectiveThe aim of this study was to determine the effect of age of obesity onset on senescence‐related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss.MethodsAB and FEM SAT were collected from human females with childhood‐onset obesity (CO) or adult‐onset obesity (AO) before and after diet‐ and exercise‐induced weight loss. Immunofluorescence analysis of γH2AX/RAD51 (DNA damage/repair markers) and p53/p21 (senescence markers) was conducted in cultured preadipocytes, and senescence‐associated β‐galactosidase (SA‐β‐gal) activity was measured in SAT.ResultsCO had proportionately more AB and FEM preadipocytes with DNA damage (γH2AX+) and senescence markers (p53+ and/or p21+) than AO at baseline. The proportion of γH2AX+ FEM preadipocytes declined with weight loss in CO and was similar between groups after weight loss. The number of γH2AX foci in γH2AX+ preadipocytes decreased similarly between groups and regions with weight loss in parallel with an increase in RAD51. The proportion of p53+ and p21+ preadipocytes and SA‐β‐gal+ cells in SAT did not change with weight loss, but the total p21 intensity in p53+/p21+ FEM preadipocytes declined in AO.ConclusionsThese results provide preliminary evidence that females with CO have an accelerated preadipocyte aging state that improves with weight loss in terms of DNA damage but not senescence.