Halfmann, Peter J
Mayo Clinic
Department of Pathobiological Sciences, University of Wisconsin-Madison, 2015 Linden Dr, Madison, WI 53706, USA.
Citations 2
Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual
Halfmann, Peter , Minor, Nicholas R. , Haddock, Luis A. , Maddox, Robert James, Riemersa, Kasen K., Prasad, A. Mallikarjuna, Alman, Kirsten J., Florek, Kelsey R. , Bateman, Allen , Safdar, Nasia , Andes, David R. , Kawaoka, Yoshihiro , Yao, Joseph D. , O’Connor, David H. , Halfmann, Peter J , Haddock Iii, Luis A , Florek, Kelsey , O'Connor, David H , Maddox, Robert, Moreno, Gage K. , Braun, Katarina M. , Baker, David , Prasad, Ankur, Lambert, Matthew C, Westergaard, Ryan P. , Fida, Madiha , Friedrich, Thomas C.
Virus Evolution | November 5, 2022 | Volume: 9 | Issue: 2 | Pages: No page available
Abstract Prolonged infections in immunocompromised individuals may be a source for novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants, particularly when both the immune system and antiviral therapy fail to clear the infection and enable within-host evolution. Here we describe a 486-day case of SARS-CoV-2 infection in an immunocompromised individual. Following monotherapy with the monoclonal antibody Bamlanivimab, the individual’s virus acquired resistance, likely via the earliest known occurrence of Spike amino acid variant E484T. Recently, E484T has arisen again as a derivative of E484A in the Omicron Variant of Concern, supporting the hypothesis that prolonged infections can give rise to novel variants long before they become prevalent in the human population.
Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition
Navaratnarajah, Chanakha K. , Pease, David R. , Halfmann, Peter , Barkhymer, Alison , Howell, Kyle G., Charlesworth, Jon E. , Christensen, Trace , Kawaoka, Yoshihiro , Cattaneo, Roberto , Schneider, Jay W. , Taye, Biruhalem , Cattaneo, Roberto , Schneider, Jay W , Halfmann, Peter J
Journal of Virology | October 6, 2021 | Volume: 95 | Issue: 24 | Pages: No page available
Cardiac complications frequently observed in COVID-19 patients are tentatively attributed to systemic inflammation and thrombosis, but viral replication has occasionally been confirmed in cardiac tissue autopsy materials. We developed an in vitro model of SARS-CoV-2 spread in myocardium using induced pluripotent stem cell-derived cardiomyocytes.