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Nalleballe, Krishna

0000-0003-4943-171X

Mayo Clinic

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Citations 1

CD8 Encephalitis: A Diagnostic Dilemma
Sharma, Rohan , Spradley, Thomas, Campbell, Morgan , Biyani, Shubham, Singhal, Pulkit, Nalleballe, Krishna , Gökden, Murat , Kapoor, Nidhi , Nalleballe, Krishna , Campbell, Morgan, Elkhider, Hisham , Kumar, Manoj

Diagnostics | November 4, 2022 | Volume: 12 | Issue: 11 | Pages: 2687

10.3390/diagnostics12112687 Get It

CD8+ encephalitis is a subacute encephalopathy associated with HIV infection. Pathophysiology is thought to be auto-reactive CD8+ cells attacking on HIV infected CD4+ cells and ‘viral escape’ phenomena (replication of CD8+ cells in CSF). We present a case of a 45-year-old man with well controlled HIV who developed CD8 encephalitis following Herpes simplex encephalitis. He had persistent encephalopathy for several weeks with status epilepticus and agitated delirium, and diagnosis remained elusive until a brain biopsy confirmed the diagnosis.