Citations 3
Phase 1 first-in-human study of MEDI2228, a BCMA-targeted ADC, in patients with relapsed refractory multiple myeloma
Migkou, Magdalini , Bhutani, Manisha , Kalff, Anna , Walcott, Farzana L. , Pore, Nabendu , Brown, Miranda, Wang, Fujun, Cheng, Lily , Kagiampakis, Ioannis, Williams, Marna, Wu, Yuling , Kubiak, Robert J., Zonder, Jeffrey A. , Larsen, Jeremy T. , Sirdesai, Shreerang, Kumar, Shaji , Larsen, Jeremy, Kumar, Shaji K , Dimopoulos, Meletios Α. , Ailawadhi, Sikander , Kinneer, Krista , Jiang, Yu Yan , Kubiak, Robert J., Yee, Andrew J
Leukemia & Lymphoma | October 15, 2024 | Volume: 65 | Issue: 12 | Pages: 1789-1800
Risk factors for severe infection and mortality In patients with COVID‐19 in patients with multiple myeloma and AL amyloidosis
Ho, Matthew , Zanwar, Saurabh , Ailawadhi, Sikander , Larsen, Jeremy T. , Bergsagel, Leif, Binder, Moritz , Chanan‐Khan, Asher , Dingli, David , Hayman, Suzanne R. , Kapoor, Prashant , Kourelis, Taxiarchis , Lacy, Martha Q. , Sher, Taimur , Warsame, Rahma , Fonder, Amie , Hobbs, Miriam, Hwa, Yi L. , Kyle, Robert A. , Kumar, Shaji , Bergsagel, P. Leif , Bergsagel, P. Leif , Ailawadhi, Sikander , Larsen, Jeremy, Binder, Moritz , Dispenzieri, Angela , Gertz, Morie A , Gonsalves, Wilson , Kourelis, Taxiarchis , Leung, Nelson , Muchtar, E , Warsame, Rahma , Hwa, Yi L , Rajkumar, S Vincent , Kumar, Shaji K , Dingli, David , Ho, Matthew , Buadi, Francis K. , Dispenzieri, Angela , Fonseca, Rafaël , Gertz, Morie A. , Gonsalves, Wilson I. , Go, Ronald S. , Leung, Nelson , Lin, Yi , Muchtar, Eli , Roy, Vivek , Rajkumar, S. Vincent
American Journal of Hematology | October 13, 2022 | Volume: 98 | Issue: 1 | Pages: 49-55
AbstractPatients with multiple myeloma (MM) have a lower efficacy from COVID‐19 vaccination and a high rate of mortality from COVID‐19 in hospitalized patients. However, the overall rate and severity of COVID‐19 infection in all settings (including non‐hospitalized patients) and the independent impact of plasma cell‐directed therapies on outcomes needs further study. We reviewed the medical records of 9225 patients with MM or AL amyloidosis (AL) seen at Mayo Clinic Rochester, Arizona, and Florida between 12/01/2019 and 8/31/2021 and identified 187 patients with a COVID‐19 infection (n = 174 MM, n = 13 AL). The infection rate in our cohort was relatively low at 2% but one‐fourth of the COVID‐19 infections were severe. Nineteen (10%) patients required intensive care unit (ICU) admission and 5 (3%) patients required mechanical ventilation. The mortality rate among hospitalized patients with COVID‐19 was 22% (16/72 patients). Among patients that were fully vaccinated at the time of infection (n = 12), two (17%) developed severe COVID‐19 infection, without any COVID‐related death. On multivariable analysis, treatment with CD38 antibody within 6 months of COVID‐19 infection [Risk ratio (RR) 3.6 (95% CI: 1.2, 10.5), p = .02], cardiac [RR 4.1 (95% CI: 1.3, 12.4), p = .014] or pulmonary comorbidities [RR 3.6 (95% CI 1.1, 11.6); p = .029] were independent predictors for ICU admission. Cardiac comorbidity [RR 2.6 (95% CI: 1.1, 6.5), p = .038] was an independent predictor of mortality whereas MM/AL in remission was associated with lower mortality [RR 0.4 (95% CI: 0.2–0.8); p = .008].
Risk factors for severe infection and mortality in COVID-19 and monoclonal gammopathy of undetermined significance
Zanwar, Saurabh , Buadi, Francis K. , Larsen, Jeremy T. , Bergsagel, Leif, Binder, Moritz , Chanan‐Khan, Asher , Dingli, David , Hayman, Suzanne R. , Kapoor, Prashant , Kourelis, Taxiarchis , Lacy, Martha Q. , Sher, Taimur , Warsame, Rahma , Fonder, Amie , Hobbs, Miriam, Hwa, Yi L. , Kyle, Robert A. , Kumar, Shaji , Bergsagel, P. Leif , Bergsagel, P. Leif , Ho, Matthew , Buadi, Francis K , Larsen, Jeremy, Binder, Moritz , Chanan-Khan, Asher , Dispenzieri, Angela , Kourelis, Taxiarchis , Lacy, Martha Q , Leung, Nelson , Muchtar, E , Roy, Vivek , Warsame, Rahma , Fonder, Amie , Kumar, Shaji K , Dingli, David , Ho, Matthew , Ailawadhi, Sikander , Dispenzieri, Angela , Fonseca, Rafaël , Gertz, Morie A. , Gonsalves, Wilson I. , Go, Ronald S. , Leung, Nelson , Lin, Yi , Muchtar, Eli , Roy, Vivek , Rajkumar, S. Vincent
Blood | September 12, 2022 | Volume: 140 | Issue: 18 | Pages: 1997-2000
Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse outcomes with COVID-19, finding no association between CHIP and 28-day mortality while providing data indirectly linking IL-6 signaling and patient outcomes. In the second article, Ho and colleagues investigate the outcomes of patients with monoclonal gammopathy of undetermined significance (MGUS) with COVID-19, reporting that one-fourth had a severe infection and that on multivariable analysis, adverse outcomes are more likely if immunoparesis is present.