Sun, Ying Hao
Mayo Clinic
Cincinnati Children's Hospital Medical Center
Citations 1
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
Liu, Xiaona , Chhipa, Rishi Raj , Pooya, Shabnam, Wortman, Matthew D. , Yachyshin, Sara, Chow, Lionel M.L. , Zhou, Xuan , McPherson, Christopher, Warnick, Ronald E. , Kendler, Ady , Poels, Jeroen, Norga, Koen , Viollet, Benoı̂t , Grabowski, Gregory A. , Dasgupta, Biplab , Kumar, Ashish , Sun, Ying Hao , Quinn, Brian , Giri, Shailendra , Viollet, Benoit
Proceedings of the National Academy of Sciences | January 13, 2014 | Volume: 111 | Issue: 4 | Pages: No page available
Significance Cancer cells reprogram their metabolism for optimal growth and survival. AMPK-activated protein kinase (AMPK) is a key energy sensor that controls many metabolic pathways including metabolic reprogramming. However, its role in cancer is poorly understood. Some studies claim that it has a tumor suppressor role while others show its protumor role. Two AMPK-activating compounds (including metformin, now in many clinical trials) are widely used to suppress cancer cell proliferation. We found that AMPK is abundantly expressed in high-grade gliomas and, in contrast to popular belief, these two AMPK activators suppressed glioma cell proliferation through unique AMPK-independent mechanisms.