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An, Kai‐Nan

Mayo Clinic

Mayo Clinic

Citations 24

Surgical capsular release reduces flexion contracture in a rabbit model of arthrofibrosis
An, Kai‐Nan, Steinmann, Scott P. , Morrey, B.F. , Barlow, Jonathan D. , Hartzler, Robert U. , Abdel, Matthew P. , Morrey, Mark E. , An, Kai‐Nan , Sánchez‐Sotelo, Joaquín

Journal of Orthopaedic Research | May 23, 2013 | Volume: 31 | Issue: 10 | Pages: 1529-1532

10.1002/jor.22385 Get It

ABSTRACTAnimal models of joint contracture may be used to elucidate the mechanisms of arthrofibrosis. Patients with joint contracture commonly undergo surgical capsular release. Previous animal models of joint contracture do not simulate this aspect of arthrofibrosis. We hypothesize that a surgical capsular release will decrease the severity of arthrofibrosis in this rabbit model. A capsular contracture was surgically created in 20 skeletally mature rabbits. Eight weeks later, ten rabbits underwent capsular release, which consisted of elevation of the posterior capsule through a lateral incision and manipulation under anesthesia. Ten rabbits had a sham incision, without release (control group). Immediately after release or sham surgery, extension loss (calculated by subtracting the knee extension angle (degrees) of the operative limb from the nonoperative, contralateral limb) was measured using fluoroscopy. All animals were sacrificed following 16 weeks of postoperative free cage activity. At sacrifice, joint contracture was measured using a custom, calibrated device. The histology of the posterior joint capsule was assessed at sacrifice. All animals survived both operations without complications. Immediately after surgical release or sham surgery, the average extension loss was 129.2 ± 10.7° in the control group versus 29.6 ± 8.2° in the capsular release group (p = 0.0002). Following 16 weeks of remobilization, the average extension loss of the control and capsular release animals were 49.0 ± 12.7° and 36.5 ± 14.2°, respectively (p = 0.035). There were no histological differences between the two groups. In this animal model, a surgical capsular release decreased the extension loss (flexion contracture) immediately after surgery, as well as following sixteen weeks of remobilization. There were no histological changes detected in the posterior joint capsule. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1529–1532, 2013
Evaluation of Fracture Resistance in Aqueous Environment of Four Restorative Systems for Posterior Applications. Part 1
Dhima, Matilda, Assad, Daniel, Volz, John E., An, Kai‐Nan, Berglund, Lawrence J., Carr, Alan B. , Salinas, Thomas

Journal of Prosthodontics | December 22, 2012 | Volume: 22 | Issue: 4 | Pages: 256-260

10.1111/j.1532-849x.2012.00948.x Get It

AbstractPurposeThe goals of this study were to: (1) establish a range of the performance of four restorative systems for posterior single‐tooth crowns under single load to fracture submerged in an aqueous environment, (2) identify restorative system(s) of interest to be examined in the second study phase under sliding contact step‐stress fatigue as full‐contour anatomically appropriate single posterior tooth restoration(s), (3) establish a range for loading/testing for phase 2.Materials and MethodsForty specimens (n = 10/group) of 2 mm uniform thickness were tested. Group 1: monolithic lithium disilicate IPS e.max Press; group 2: IPS e.max ZirPress, 0.8 mm zirconia core with 1.2 mm pressed veneering porcelain; group 3: IPS e.max ZirPress, 0.4 mm zirconia core with 1.6 mm pressed veneering porcelain; group 4: IPS InLine PoM. Specimens were bonded to a block of polycast acrylic resin on a 30° sloped surface with resin cement. Specimens were axially single loaded to failure while submerged under water.ResultsThere was a statistically significant difference (p < 0.001) in failure load among the four restorative systems. Lithium disilicate showed a mean failure load similar to mean maximum posterior bite forces (743.1 ± 114.3 N). IPS e.max Zirpress with a 0.4 mm zirconia core exhibited the lowest mean failure load (371.4 ± 123.0 N).ConclusionFracture resistance of monolithic lithium disilicate in an aqueous environment is promising and requires second phase testing to evaluate the potential of various thicknesses appropriate for posterior single tooth applications. Doubling the IPS e.max Zirpress zirconia core from 0.4 mm to 0.8 mm increased the fracture resistance of this restorative system threefold.
A biomechanical comparison of the Delta screw and RetroScrew tibial fixation on initial intra‐articular graft tension
Rhee, Peter C. , Levy, Bruce A. , Thoreson, Andrew R. , An, Kai-Nan, Dahm, Diane L., Stuart, Michael J. , An, Kai‐Nan

Knee Surgery, Sports Traumatology, Arthroscopy | January 21, 2011 | Volume: 19 | Issue: 5 | Pages: 781-786

10.1007/s00167-010-1366-z Get It

AbstractPurposeThe purpose of this study is to determine the effect of bioabsorbable interference screw (BIS) tibial fixation with the Delta screw (antegrade) and RetroScrew (retrograde) on initial (time zero) intra‐articular graft tension in soft tissue anterior cruciate ligament (ACL) reconstruction in a cadaveric model.MethodsTen matched pairs of cadaveric tibias received one of two tibial fixation constructs using quadrupled hamstring grafts, Delta screw (antegrade) or the RetroScrew (retrograde). Each specimen was mounted to the materials testing device with the displacement force vector in line with the tibial tunnel. The construct was pre‐tensioned (10–30 N, 0.1 Hz, 10 cycles), a baseline tension of 25 N was introduced, and the change in intra‐articular graft tension before and after screw insertion was recorded.ResultsSegmental (proximal, middle, distal) BMD was utilized to assess BMD using quantitative computed tomography (qCT). The Delta screw had a higher maximum insertion torque (P = 0.03) and exhibited a larger increase in intra‐articular graft tension as compared to the RetroScrew (38.3 ± 17.9 N, 7.6 N ± 14.4, P = 0.004), respectively. There were no significant correlations between intra‐articular graft tension increase to maximum insertion torque (P = NS) or corresponding segmental BMD (P = NS).ConclusionsDelta screw tibial fixation (antegrade) in soft tissue ACL reconstruction significantly increases the initial intra‐articular graft tension as compared to RetroScrew screw fixation (retrograde) in this cadaveric model. Delta screw (antegrade) tibial fixation may increase initial quadrupled hamstring graft intra‐articular tension with currently accepted insertion techniques.
Intraarticular pressure and capacity of the elbow
O’Driscoll, Shawn W. , Morrey, B.F. , An, Kai‐Nan, An, Kai‐Nan, Fitzsimmons, James S

Arthroscopy | April 22, 2004 | Volume: 6 | Issue: 2 | Pages: 100-103

10.1016/0749-8063(90)90007-z Get It

Abstract The compliance, capacity, and the position of minimum intraarticular pressure were measured in 13 thawed, fresh‐frozen human elbows. The capacity of the joint capsule was 23 ± 4 ml. The intraarticular pressure was the lowest at 80° of flexion. Capsular rupture occurred at relatively low intraarticular pressures—80 ± 42 mm Hg. Knowledge of the capacity of the normal elbow joint combined with the fact that this joint capsule tends to rupture or permit extravasation of fluid into the periarticular soft tissues should be considered when infusing fluids during arthroscopy. Finally, the “resting position” of 80° of flexion minimizes capsular tension and therefore might contribute to the development of joint contracture associated with prolonged immobilization in this position. This would be consistent with the observation that patients with posttraumatic elbow stiffness have an average arc of flexion of 60–90°.