Citations 1
A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression
Khurana, Satish , Buckley, Shannon M. , Schouteden, Sarah, Ekker, Stephen C. , Petryk, Anna , Delforge, Michel, Zwijsen, An , Verfaillie, Catherine M. , Ekker, Stephen C , Verfaillie, Catherine
Blood | December 14, 2012 | Volume: 121 | Issue: 5 | Pages: 781-790
Key PointsCytokine-induced loss of murine as well as human HSPC homing during ex vivo culture can be prevented by addition of BMP4. In HSPCs, BMP4 directly regulates Integrin-α4 expression through SMAD-independent p38 MAPK-mediated signaling.