Medalla, Maria
Mayo Clinic
Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Citations 2
Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice
Delpech, Jean-Christophe , Pathak, Dhruba , Varghese, Merina , Kalavai, Srinidhi Venkatesan , Hays, Emma C. , Hof, Patrick R. , Johnson, W. Evan , Ikezu, Seiko , Luebke, Jennifer I. , Ikezu, Tsuneya , Medalla, Maria , Luebke, Jennifer I , Ikezu, Tsuneya , Medalla, Maria
Science Translational Medicine | September 15, 2021 | Volume: 13 | Issue: 611 | Pages: No page available
Wolframin-1–positive neurons in the entorhinal cortex of mouse brain propagate tau to the hippocampal CA1 region resulting in memory impairment.
TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau
Ash, Peter E.A. , Lei, Shuwen , Shattuck, Jenifer E., Boudeau, Samantha, Carlomagno, Yari , Medalla, Maria , Mashimo, Bryce L. , Socorro, Guillermo , Al-Mohanna, Louloua F. A., Jiang, Lulu , Öztürk, Muhammet M., Knobel, Mark, Ivanov, Pavel , Petrucelli, Leonard , Wegmann, Susanne , Kanaan, Nicholas M. , Wolozin, Benjamin , Medalla, Maria , Lei, Shuwen, Wolozin, Benjamin
Proceedings of the National Academy of Sciences | February 22, 2021 | Volume: 118 | Issue: 9 | Pages: No page available
Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents are typically used and the resulting tau is not toxic. We now demonstrate that TIA1 potentiates RNA-mediated phase separation of tau, thereby enabling a process that occurs at physiological concentrations and also directs the formation of biologically active, highly neurotoxic oligomeric tau. Coordinated phase separation of functionally related proteins provides a general mechanism through which membraneless organelles can direct biological activities.