Kwon, Minseok
Mayo Clinic
Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Citations 1
Landmarks of human embryonic development inscribed in somatic mutations
Bizzotto, Sara , Dou, Yanmei , Ganz, Javier , Doan, Ryan N. , Kwon, Min‐Seok , Bohrson, Craig L. , Kim, Sonia N. , Bae, Taejeong , Abyzov, Alexej , Network, NIMH Brain Somatic Mosaicism, Park, Peter J. , Galor, Alon , Yang, Xiaoxu , Kwon, Minseok , Walsh, Christopher A , Abyzov, Alexej , Bae, Taejeong , Park, Peter J , Network, NIMH Brain Somatic Mosaicism, Walsh, Christopher A.
Science | March 18, 2021 | Volume: 371 | Issue: 6535 | Pages: 1249-1253
Mutations provide an enduring record Somatic mutations pepper our cells with change, but because they are not in the germline, they do not propagate to the next generation. Bizzotto et al. leveraged data on the distribution of somatic mutations in adults to take a backward look at the earliest moments of human development. Calculation of cellular lineages on the basis of shared somatic mutations shows the number of cells from which the body will develop when the human embryo gastrulates. The lineage for forebrain cells is identifiable, as are the asymmetrical fates spun out of many of the gastrula cells. Science , this issue p. 1249