Jordan, Kyra
Mayo Clinic
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Citations 1
Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching
Zhao, Yu , Zhu, Xiang-Yang, Song, Turun , Zhang, Lei , Eirin, Alfonso , Conley, Sabena M., Tang, Hui , Saadiq, Ishran M. , Jordan, Kyra L., Lerman, Lilach O. , Conley, Sabena, Saadiq, Ishran, Jordan, Kyra, Lerman, Lilach O , Eirin, Alfonso , Lerman, Amir
American Journal of Physiology-Renal Physiology | February 8, 2021 | Volume: 320 | Issue: 3 | Pages: F454-F463
Tumor necrosis factor-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of MSCs, but its ability to protect the ischemic kidney is unknown. In pigs with renal artery stenosis, we show that MSC delivery increased renal vein TSG-6, decreased kidney inflammatory macrophages, and improved renal function. In vitro, TSG-6 decreased inflammatory macrophages and tubular cell injury. Therefore, TSG-6 released from MSCs may decrease renal tubular cell injury, which is associated with regulating macrophage function and phenotype.