Colmenares Aguilar, Maria-Gabriela
Mayo Clinic
Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Citations 1
Expression of the regulated isoform of the electrogenic Na+/HCO3− cotransporter, NBCe1, is enriched in pacemaker interstitial cells of Cajal
Aguilar, Maria Gabriela Colmenares , Mazzone, Amelia , Eisenman, Seth T., Strege, Peter R. , Bernard, Cheryl E., Holmes, Heather L. , Romero, Michael F. , Farrugia, Gianrico , Gibbons, Simon J. , Colmenares Aguilar, Maria-Gabriela, Gibbons, S J , Romero, Michael F , Strege, Peter R , Mazzone, Amelia
American Journal of Physiology-Gastrointestinal and Liver Physiology | October 28, 2020 | Volume: 320 | Issue: 1 | Pages: G93-G107
In this study, we show that the electrogenic Na+/HCO3− cotransporter, NBCe1/Slc4a4, is expressed in subtypes of interstitial cells of Cajal (ICCs) responsible for electrical slow wave generation throughout the mouse gastrointestinal tract and is absent in other types of ICCs. The transcripts of Slc4a4 expressed in mouse ICCs and human gastrointestinal smooth muscle are the regulated isoforms. This indicates a key role for HCO3- transport in generation of gastrointestinal motility patterns.