Brown, Alyssa D
Mayo Clinic
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota.
Citations 2
Women Physicians and the Suffrage Movement
Chin, Eliza Lo, Levy, Morgan S. , Brown, Alyssa , Marr, Mollie , Keni, Prachi M, Daram, Naveena , Chau, Courtney A. , Rangwala, Naseem, Watson, Katarina Q., Brown, Alyssa D, Brown, Alyssa D
The Permanente Journal | October 8, 2020 | Volume: 24 | Issue: 3 | Pages: No page available
Phrenic motor neuron loss in an animal model of early onset hypertonia
Brandenburg, Joline E. , Fogarty, Matthew J. , Brown, Alyssa , Brown, Alyssa D, Brown, Alyssa D , Sieck, Gary C. , Fogarty, Matthew J
Journal of Neurophysiology | April 1, 2020 | Volume: 123 | Issue: 5 | Pages: 1682-1690
Phrenic motor neuron (PhMN) development in early onset hypertonia is poorly understood. Yet, respiratory disorders are a common cause of morbidity and mortality. In spa mice, an animal model of early onset hypertonia, we found ~30% fewer PhMNs, compared with controls. This PhMN loss disproportionately affected larger PhMNs. Thus, the number and heterogeneity of the PhMN pool are decreased in spa mice, likely contributing to the hypertonia, impaired neuromotor control, and respiratory disorders.