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Black, John L

0000-0001-6726-7293

Mayo Clinic

Division of Laboratory Genetics and Genomics, Personalized Genomics Laboratory, Mayo Clinic Laboratories, Mayo Clinic, Rochester, Minnesota, USA.

Citations 1

PharmVar GeneFocus: CYP2D6
Nofziger, Charity , Turner, Amy , Whirl‐Carrillo, Michelle , Agúndez, José A. G. , Black, John L. , Dunnenberger, Henry M. , Ruaño, Gualberto , Kennedy, Martin A. , Hachad, Houda , Klein, Teri E. , Turner, Amy J , Whirl-Carrillo, Michelle , Agúndez, José A G , Black, John L , Dunnenberger, Henry M , Kennedy, Martin A , Hachad, Houda , Gaedigk, Andrea , Klein, Teri E , Sangkuhl, Katrin , Phillips, Michael , Gaedigk, Andrea

Clinical Pharmacology & Therapeutics | September 23, 2019 | Volume: 107 | Issue: 1 | Pages: 154-170

10.1002/cpt.1643 Get It

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).