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Lennon, Vanda

Mayo Clinic

Department of Laboratory Medicine and Pathology (K.O'.C., A.Z., V.L., S.J.P., A.M.), Department of Neurology (A.Z., V.L., S.J.P., A.M.), and Department of Immunology (V.L.), Mayo Clinic, Rochester, MN; Oxford Autoimmune Neurology Group (P.J.W., V.C.M.), Nu

Citations 3

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity
Segal‬‏, Yahel , Mangioris, Georgios , Lennon, Vanda A. , Yang, Binxia , Dubey, Divyanshu , McKeon, Andrew , Mills, John R. , Tolédano, Michel B. , Vodopivec, Ivana, Pittock, Sean J. , Ζεκερίδου, Αναστασία , Dubey, Divyanshu , Pittock, S J , Lennon, Vanda, McKeon, Andrew , Zekeridou, Anastasia , Dubey, Divyanshu , Yang, Binxia , Flanagan, Eoin P. , Toledano, Michel

Annals of Clinical and Translational Neurology | January 27, 2025 | Volume: 12 | Issue: 4 | Pages: 855-860

10.1002/acn3.52305 Get It

AbstractDefining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne). Controls included non‐inflammatory (N = 42), AQP4‐IgG‐positive (N = 83), CNS infections (N = 13), and neurosarcoidosis (N = 32). IL5, IL6, IL10, IL8/CXCL8, CXCL9, CXCL10, CXCL13, BAFF, GM‐CSF, IFN‐gamma, and TNF‐alpha concentrations were higher compared to non‐inflammatory controls (P < 0.01). GFAP concentrations were similar to those of AQP4‐IgG‐positive patients; NfL was higher (P < 0.001) and correlated with MRI changes and outcomes. CSF cytokine/chemokine findings in GFAP autoimmunity correlate with histopathology; GFAP and NfL hold promise as disease biomarkers.
Phosphodiesterase 10A IgG
Ζεκερίδου, Αναστασία , Kryzer, Thomas J., Guo, Yong , Hassan, Anhar , Lennon, Vanda A. , Lucchinetti, Claudia F. , Pittock, Sean J. , Kryzer, Thomas, Lennon, Vanda, Pittock, S J , Guo, Yong , McKeon, Andrew

Neurology | July 17, 2019 | Volume: 93 | Issue: 8 | Pages: No page available

10.1212/wnl.0000000000007971 Get It

GABA A receptor autoimmunity
Waters, Patrick , Komorowski, Lars , Ζεκερίδου, Αναστασία , Guo, Chu-Yueh, Mgbachi, Victor , Probst, Christian , Mindorf, Swantje , Teegen, Bianca , Geschwind, Michael D. , Lennon, Vanda A. , Pittock, Sean J. , McKeon, Andrew , O'Connor, Kevin, Mgbachi, Victor C, Lennon, Vanda, Pittock, S J , McKeon, Andrew , Waters, Patrick J , O’Connor, Kevin C. , Gelfand, Jeffrey M.

Neurology Neuroimmunology & Neuroinflammation | April 5, 2019 | Volume: 6 | Issue: 3 | Pages: No page available

10.1212/nxi.0000000000000552 Get It