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Kaewput, Wisit

0000-0003-2920-7235

Mayo Clinic

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.

Citations 71

Epidemiology and Prognostic Importance of Atrial Fibrillation in Kidney Transplant Recipients: A Meta-Analysis
Bathini, Tarun , Khoury, Nadeen , Sharma, Konika , Ungprasert, Patompong , Aeddula, Narothama Reddy , Watthanasuntorn, Kanramon , Salim, Sohail Abdul , Kaewput, Wisit , Koller, F., Cheungpasitporn, Wisit , Aeddula, Narothama Reddy , Kaewput, Wisit , Cheungpasitporn, Wisit , Khoury, Nadeen , Thongprayoon, Charat , Chokesuwattanaskul, Ronpichai , Bathini, Tarun , Prasitlumkum, Narut

Journal of Clinical Medicine | October 19, 2018 | Volume: 7 | Issue: 10 | Pages: 370

10.3390/jcm7100370 Get It

This meta-analysis was conducted with the aims to summarize all available evidence on (1) prevalence of pre-existing atrial fibrillation (AF) and/or incidence of AF following kidney transplantation; (2) the outcomes of kidney transplant recipients with AF; and (3) the trends of estimated incidence of AF following kidney transplantation over time. A literature search was conducted utilizing MEDLINE, EMBASE, and the Cochrane Database from inception through March 2018. We included studies that reported (1) prevalence of pre-existing AF or incidence of AF following kidney transplantation or (2) outcomes of kidney transplant recipients with AF. Effect estimates from the individual study were extracted and combined utilizing random-effect, generic inverse variance method of DerSimonian and Laird. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42018086192). Eight cohort studies with 137,709 kidney transplant recipients were enrolled. Overall, the pooled estimated prevalence of pre-existing AF in patients undergoing kidney transplantation was 7.0% (95% CI: 5.6–8.8%) and pooled estimated incidence of AF following kidney transplantation was 4.9% (95% CI: 1.7–13.0%). Meta-regression analyses were performed and showed no significant correlations between year of study and either prevalence of pre-existing AF (p = 0.93) or post-operative AF after kidney transplantation (p = 0.16). The pooled odds ratios (OR) of mortality among kidney transplant recipients with AF was 1.86 (3 studies; 95% CI: 1.03–3.35). In addition, AF is also associated with death-censored allograft loss (2 studies; OR: 1.55, 95% CI: 1.02–2.35) and stroke (3 studies; OR: 2.54, 95% CI: 1.11–5.78) among kidney transplant recipients. Despite advances in medicine, incidence of AF following kidney transplant does not seem to decrease over time. In addition, there is a significant association of AF with increased mortality, allograft loss, and stroke after kidney transplantation.