Li, Joyce H
Mayo Clinic
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655.
Citations 1
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
Alcaino, Constanza , Knutson, Kaitlyn R. , Treichel, Anthony J. , Yildiz, Gulcan , Strege, Peter R. , Li, Joyce H. , Leiter, Andrew B. , Szurszewski, Joseph H., Farrugia, Gianrico , Li, Joyce H , Farrugia, Gianrico , Beyder, Arthur , Treichel, Anthony J , Strege, Peter R , Linden, David R. , Beyder, Arthur
Proceedings of the National Academy of Sciences | July 23, 2018 | Volume: 115 | Issue: 32 | Pages: No page available
Significance Mechanical forces are important for normal gastrointestinal tract function. The enterochromaffin cells in the gastrointestinal epithelium have been proposed, but not previously shown, to be specialized sensors that convert forces into serotonin release, and serotonin released from these cells is important for normal gastrointestinal secretion and motility. The findings in this study show that some enterochromaffin cells are indeed mechanosensitive, and that they use mechanosensitive Piezo2 channels to generate an ionic current that is critical for the intracellular Ca 2+ increase, serotonin release, and epithelial fluid secretion.