Back to Authors

Jairath, V

0000-0003-1590-0338

Mayo Clinic

Robarts Clinical Trials, Western University, London, ON, Canada.

Citations 27

Editorial: histologic normalisation in ulcerative colitis
Pai, Rish K. , Jairath, Vipul , Feagan, Brian G. , Jairath, Vipul , Jairath, Vipul , Jairath, V , Jairath, V , Jairath, Vipul

Alimentary Pharmacology & Therapeutics | January 16, 2020 | Volume: 51 | Issue: 3 | Pages: 399-401

10.1111/apt.15617 Get It

LINKED CONTENTThis article is linked to Cushing et al and Cushing and Ananthakrishnan papers. To view these articles, visit https://doi.org/10.1111/apt.15568 and https://doi.org/10.1111/apt.15621.
Editorial: evolving histological assessment of NASH. Authors' reply
Pai, Rish K. , Feagan, Brian G. , Parker, Claire E. , Jairath, Vipul , Loomba, Rohit , Jairath, Vipul , Jairath, Vipul , Jairath, V , Jairath, V , Loomba, Rohit , Jairath, Vipul

Alimentary Pharmacology & Therapeutics | November 11, 2019 | Volume: 50 | Issue: 11-12 | Pages: 1245-1246

10.1111/apt.15570 Get It

LINKED CONTENTThis article is linked to Pai et al and Rowe papers. To view these articles, visit https://doi.org/10.1111/apt.15503 and https://doi.org/10.1111/apt.15537.
P413 A simple scoring tool predicts exposure–response relationship, onset of action, response to interval shortening, and surgical risk with vedolizumab therapy for Crohn’s disease
Dulai, Parambir S. , Amiot, Aurélien , Singh, Siddharth , Serrero, Mélanie , Jairath, Vipul , Filippi, Jérôme, Kane, Sunanda V. , Bouhnik, Yoram , Sandborn, William J. , Lasch, Karen, Rosario, Maria , Feagan, Brian G. , Bojic, Daniela, Trang-Poisson, Caroline, Shen, Bo , Altwegg, Romain , Sands, B E, Colombel, J F, Carbonnel, Franck , Bohm, Matthew , Bourrier, Anne, Jairath, Vipul , Jairath, Vipul , Jairath, V , Jairath, V , Jairath, Vipul , Peyrin‐Biroulet, Laurent , Pariente, Benjamin , Loftus, Edward V. , Roblin, Xavier , Buisson, Anthony , Siegel, Corey A , Trang, Caroline , Hudesman, David , Lukin, Dana J.

Journal of Crohn's and Colitis | January 25, 2019 | Volume: 13 | Issue: Supplement_1 | Pages: S316-S316

10.1093/ecco-jcc/jjy222.537 Get It

P631 Development and validation of a clinical scoring tool for predicting treatment outcomes with vedolizumab in patients with ulcerative colitis
Dulai, Parambir S. , Singh, Siddharth , Meserve, Joseph , Chablaney, Shreya , Shashi, Preeti , Kochhar, Gursimran , Weiss, Aaron , Koliani‐Pace, Jenna L., Gao, Youran, Boland, Brigid S. , Hirten, Robert , Sultan, Keith , Bohm, Matthew , Varma, Sashidhar, Fischer, Monika , Shmidt, Eugenia , Rosario, Maria , Jairath, Vipul , Feagan, Brian G. , Shen, Bo , Kane, Sunanda V. , Sandborn, William J. , Sands, B E, Colombel, J F, Lasch, Karen, Cao, Chang , Jairath, Vipul , Jairath, Vipul , Jairath, V , Jairath, V , Jairath, Vipul , Casteele, Niels Vande , Winters, Adam C. , Aniwan, Satimai , Weiss, A, Chang, John T. , Faleck, David M. , Ungaro, Ryan C. , Lukin, Dana J. , Hudesman, David , Chang, Sam S. , Swaminath, Arun C. , Gupta, Nitin Kumar , Guizzetti, Leonardo , Siegel, Corey A , Loftus, Edward V.

Journal of Crohn's and Colitis | January 25, 2019 | Volume: 13 | Issue: Supplement_1 | Pages: S433-S433

10.1093/ecco-jcc/jjy222.755 Get It

Definitions of response and remission for the Robarts Histopathology Index
Pai, Rish K. , Khanna, Reena , D’Haens, Geert , Sandborn, William J. , Jeyarajah, Jenny , Feagan, Brian G. , Casteele, Niels Vande , Jairath, Vipul , Jairath, Vipul , Jairath, Vipul , Vande Casteele, N , Jairath, V , Jairath, V , Jairath, Vipul

Gut | October 26, 2018 | Volume: 68 | Issue: 11 | Pages: 2101-2102

10.1136/gutjnl-2018-317547 Get It

Editorial: validating reliability of the eosinophilic oesophagitis histological scoring system (EOE‐HSS)—an important first step. Authors’ reply
Pai, Rish K. , Bredenoord, Albert J. , Feagan, Brian G. , Jairath, Vipul , Jairath, Vipul , Jairath, Vipul , Feagan, B G , Jairath, V , Jairath, V , Jairath, Vipul

Alimentary Pharmacology & Therapeutics | May 31, 2018 | Volume: 47 | Issue: 12 | Pages: 1714-1715

10.1111/apt.14658 Get It

Linked contentThis article is linked to Warners et al and Conner and Kirsch papers. To view these articles https://doi.org/10.1111/apt.14559 and https://doi.org/10.1111/apt.14633.
Systematic review with meta‐analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis
Ma, Christopher , Guizzetti, Leonardo , Pai, Rish K. , Parker, Claire E. , Nguyen, Tran M , Khanna, Reena , Casteele, Niels Vande , D’Haens, Geert , Sandborn, William J. , Feagan, Brian G. , Ma, C , Guizzetti, L , Fedorak, R N , Pai, R K , Vande Casteele, N , D'Haens, G , Sandborn, W J , Feagan, B G , Jairath, V , Panaccione, Remo , Fedorak, Richard N. , Jairath, Vipul

Alimentary Pharmacology & Therapeutics | April 26, 2018 | Volume: 47 | Issue: 12 | Pages: 1578-1596

10.1111/apt.14672 Get It

Summary Background Regulatory requirements for claims of mucosal healing in ulcerative colitis ( UC ) will require demonstration of both endoscopic and histologic healing. Quantifying these rates is essential for future drug development. Aims To meta‐analyse endoscopic and histologic placebo response and remission rates in UC randomised controlled trials ( RCT s) and identify factors influencing these rates. Methods MEDLINE , EMBASE and the Cochrane Library were searched from inception to March 2017 for placebo‐controlled trials of pharmacological interventions for UC . Endoscopic and histologic placebo rates were pooled by random effects. Mixed effects univariable and multivariable meta‐regression was used to evaluate the influence of patient, intervention and trial‐related study‐level covariates on these rates. Results Fifty‐six induction (placebo n = 4171) and 8 maintenance trials (placebo n = 1011) were included. Pooled placebo endoscopic remission and response rates for induction trials were 23% [95 confidence interval ( CI ) 19‐28%] and 35% [95% CI 27‐42%] respectively, and 20% [95% CI 16‐24%] for maintenance of remission. The pooled histologic placebo remission rate was 14% [95% CI 8‐22%] for induction trials. High heterogeneity was observed for all outcomes ( I 2 56.2%‐88.3%). On multivariable meta‐regression, central endoscopy reading was associated with significantly lower endoscopic placebo remission rates (16% vs 25%; OR = 0.52, [95% CI 0.29‐0.92], P = 0.03). On univariable meta‐regression, higher histologic placebo remission was associated with concomitant corticosteroids ( OR = 1.17 [95% CI 1.08‐1.26], P < 0.0001, per 10% increase in corticosteroid use). Conclusions Placebo endoscopic and histologic rates range from 14% to 35% in UC RCT s but are highly heterogeneous. Outcome standardisation may reduce heterogeneity and is needed in this field.