Citations 1
PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium
Nieters, Alexandra, Conde, Lucía , Morton, Lindsay M. , Skibola, Danica R., Novak, Anne J. , Riby, Jacques, Ansell, Stephen M. , Halperin, Eran , Agana, Luz, Wang, Alice H., Roos, Anneclaire J. De , Severson, Richard K., Spinelli, John, Butterbach, Katja, Becker, Nikolaus, Sanjosé, Sílvia de , Benavente, Yolanda , Cocco, Pierluigi , Staines, Anthony , Foretová, Lenka , Brennan, Paul , Lan, Qing , Zheng, Tongzhang, Purdue, Mark P. , Armstrong, Bruce K. , Kricker, Anne , Vajdic, Claire M. , Grulich, Andrew E. , Smith, Martyn T. , Bracci, Paige M. , Hartge, Patricia, Cerhan, James R. , Wang, Sophia , Rothman, Nathaniel , Skibola, Christine F., Slager, Susan L. , Brooks‐Wilson, Angela , Shanafelt, Tait D. , Cozen, Wendy , Maynadié, Marc , Boffetta, Paolo , Zhang, Yawei , Chanock, Stephen Jacob , Cerhan, James R , Cocco, Pierluigi , Vajdic, Claire M , Morton, Lindsay M , De Roos, Anneclaire J , Wang, Sophia S
Blood | October 10, 2012 | Volume: 120 | Issue: 23 | Pages: 4645-4648
AbstractMany common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 × 10−11), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 × 10−9) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.