Panchabhai, Sonali C
Mayo Clinic
Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Citations 1
Multiple myeloma cells’ capacity to decompose H2O2 determines lenalidomide sensitivity
Sebastian, Sinto, Zhu, Yuan Xiao , Braggio, Esteban , Shi, Chang-Xin, Panchabhai, Sonali, Wier, Scott A. Van, Ahmann, Greg, Chesi, Marta , Bergsagel, P. Leif , Stewart, A. Keith, Bergsagel, P. Leif , Zhu, Yuan X, Panchabhai, Sonali C, Van Wier, Scott A, Ahmann, Greg J, Fonseca, Rafaël , Braggio, Esteban
Blood | December 28, 2016 | Volume: 129 | Issue: 8 | Pages: 991-1007
Key Points IMiDs inhibit TrxR-mediated intracellular decomposition of H2O2 and caused oxidative stress in MM cells. MM cells with lower antioxidative capacity were more vulnerable to lenalidomide-induced H2O2 accumulation and its associated cytotoxicity.