Champion, Mia
Mayo Clinic
Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ; and.
Citations 1
RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2
Zhu, Yuan Xiao , Yin, Hongwei , Bruins, Laura A., Shi, Chang-Xin, Jedlowski, Patrick , Aziz, Meraj , Sereduk, Chris , Kortuem, K. Martin, Schmidt, Jessica, Champion, Mia D., Braggio, Esteban , Stewart, A. Keith, Kortuem, Klaus Martin, Schmidt, Jessica E, Champion, Mia, Braggio, Esteban
Blood | November 14, 2014 | Volume: 125 | Issue: 3 | Pages: 483-491
Key Points High-throughput RNAi screening identified lenalidomide sensitizer genes, including RSK2, RAB, peroxisome, and potassium channel family members. Knockdown or inhibition of RSK2 synergized with lenalidomide to induce myeloma cytotoxicity and downregulation of interferon regulatory factor 4 and MYC.