Charlton, Michael R
Mayo Clinic
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Citations 2
Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease
Kim, Tae Hyo , Banini, Bubu A. , Asumda, Faizal Z., Campbell, Nellie A. , Hu, Chunling , Moser, Catherine D., Shire, Abdirashid M., Han, Shaoshan , Ma, Chenchao , Krishnan, Anuradha, Mounajjed, Taofic, White, Thomas A. , Roberts, Lewis R. , Charlton, Michael R, Roberts, Lewis R , Hu, Chunling , Campbell, Nellie A , Gores, Gregory J. , LeBrasseur, Nathan K. , Charlton, Michael
American Journal of Physiology-Gastrointestinal and Liver Physiology | July 20, 2020 | Volume: 319 | Issue: 3 | Pages: G333-G344
We report for the first time that in wild-type (WT) mice, fast-food diet (FFD) induced a threefold increase in hepatic Sulf2 mRNA and a 2.2-fold increase in sulfatase 2 (SULF2) protein expression compared with WT mice on standard chow diet (SC). We showed that knockout of SULF2 ameliorates FFD-induced obesity, hyperlipidemia, steatohepatitis, and fibrosis. These data, along with work from other laboratories, suggest that SULF2 may be critical to the ability of the liver to progress to nonalcoholic steatohepatitis and fibrosis in conditions of overnutrition.
Broadly neutralizing antibodies abrogate established hepatitis C virus infection
Dorner, Marcus , Mommersteeg, Michiel C. , Xiao, Jing , Balazs, Alejandro B. , Robbins, Justin B., Winer, Benjamin Y. , Gerges, Sherif , Vega, Kevin, Labitt, Rachael N. , Donovan, Bridget M., Giang, Erick, Krishnan, Anuradha , Chiriboga, Luis , Baltimore, David , Law, Mansun , Rice, Charles M. , Ploß, Alexander , Charlton, Michael R, Jong, Ype P. de , Charlton, Michael , Burton, Dennis R.
Science Translational Medicine | September 17, 2014 | Volume: 6 | Issue: 254 | Pages: No page available
HCV-specific neutralizing antibodies protect humanized mice from challenge and suppress established infections.